Tall blue lettuce (Lactuca biennis) is a striking native North American plant that can tower above surrounding vegetation during its flowering season. In its first year the plant forms a basal rosette of leaves close to the ground. During the second year it sends up a tall, branching stem that may reach several feet in height.

Unlike many other wild lettuces that produce yellow flowers, this species is notable for its soft blue blossoms. These delicate flowers open along slender branches during summer and attract bees, butterflies, and other pollinating insects. The plant's graceful height and unusual flower color make it a distinctive feature in meadow landscapes.

Tall blue lettuce often grows in moist soils along woodland edges, stream banks, and open meadows. Like its relatives, the plant contains a milky latex that has historically been associated with traditional herbal uses. Though not widely cultivated, it is appreciated by naturalists and native plant enthusiasts for its ecological value and elegant appearance within wild habitats.